diff --git a/.gitattributes b/.gitattributes
new file mode 100644
index 0000000000000000000000000000000000000000..9b7c16d48bd159875d83e4763fc63b46ce1bd58f
--- /dev/null
+++ b/.gitattributes
@@ -0,0 +1 @@
+*.bz2 filter=lfs diff=lfs merge=lfs -text
diff --git a/.lfsconfig b/.lfsconfig
new file mode 100644
index 0000000000000000000000000000000000000000..bc5ebe40a1b38da57b04010251bcd70657cc6a9d
--- /dev/null
+++ b/.lfsconfig
@@ -0,0 +1,2 @@
+[lfs]
+	url = https://artlfs.openeuler.openatom.cn/src-openEuler/htslib
diff --git a/htslib-1.21.tar.bz2 b/htslib-1.21.tar.bz2
deleted file mode 100644
index 7e75bc4d74548acc5b698a1a8150268737cf55c2..0000000000000000000000000000000000000000
Binary files a/htslib-1.21.tar.bz2 and /dev/null differ
diff --git a/htslib-1.22.1.tar.bz2 b/htslib-1.22.1.tar.bz2
new file mode 100644
index 0000000000000000000000000000000000000000..fa7c8c9aae89d686f1d63ee01d6ece37eda1ac55
--- /dev/null
+++ b/htslib-1.22.1.tar.bz2
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:3dfa6eeb71db719907fe3ef7c72cb2ec9965b20b58036547c858c89b58c342f7
+size 4840271
diff --git a/htslib.spec b/htslib.spec
index 05dea7ed41c72c81a553625dfe408afbf0d23030..76798ba5510b65b2bc48ca2d6ca25b3f4d3d4247 100644
--- a/htslib.spec
+++ b/htslib.spec
@@ -1,13 +1,19 @@
 Name:    htslib
-Version: 1.21
+Version: 1.22.1
 Release: 1
 Summary: C library for high-throughput sequencing data formats
-License: MIT and BSD
-URL:	 http://www.htslib.org
+License: MIT AND BSD-3-Clause
+URL:	 https://www.htslib.org
 Source0: https://github.com/samtools/htslib/releases/download/%{version}/htslib-%{version}.tar.bz2
 
-BuildRequires: 	gcc make curl-devel zlib zlib-devel bzip2-devel xz-devel libxcrypt-devel openssl-devel
-BuildRequires:  autoconf automake libtool
+BuildRequires: gcc make
+BuildRequires: bzip2-devel
+BuildRequires: curl-devel
+BuildRequires: libdeflate-devel
+BuildRequires: openssl-devel
+BuildRequires: xz-devel
+BuildRequires: zlib-devel
+
 %description
 HTSlib is an implementation of a unified C library for accessing common file 
 formats, such as SAM, CRAM and VCF, used for high-throughput sequencing data, 
@@ -38,8 +44,7 @@ the htsfile identifier tool, and the bgzip compression utility.
 %setup -q -n %{name}-%{version}
 
 %build
-%configure --prefix=%{_prefix} \
-    --libdir=%{_libdir} \
+%configure \
     --enable-plugins \
     --enable-libcurl 
 %make_build
@@ -52,6 +57,9 @@ sed -i -E '/^(Libs|Requires)\.private:/d' htslib.pc.tmp
 find %{buildroot}/%{_libdir} -iname "*.so.*" -exec chmod +x {} \;
 rm -rf %{buildroot}/%{_libdir}/libhts.a
 
+%check
+%make_build test
+
 %files
 %license LICENSE 
 %doc README NEWS README.large_positions.md
@@ -75,14 +83,19 @@ rm -rf %{buildroot}/%{_libdir}/libhts.a
 %files tools
 %{_bindir}/bgzip
 %{_bindir}/htsfile
+%{_bindir}/ref-cache
 %{_bindir}/tabix
 %{_bindir}/annot-tsv
 %{_mandir}/man1/annot-tsv.1*
 %{_mandir}/man1/bgzip.1*
 %{_mandir}/man1/htsfile.1*
+%{_mandir}/man1/ref-cache.1.*
 %{_mandir}/man1/tabix.1*
 
 %changelog
+* Tue Oct 07 2025 Funda Wang <fundawang@yeah.net> - 1.22.1-1
+- update to 1.22.1
+
 * Fri Nov 22 2024 wangxiaomeng <wangxiaomeng@kylinos.cn> - 1.21-1
 - Update to 1.21